Division of Molecular Genetics (DKFZ B060)
The Division of Molecular Genetics is aiming to uncover tumor pathomechanisms to understand the biological behavior of tumors. Research is pursued by comprehensive molecular profiling screens of tumors on the level of the genome, the methylome and/or the transcriptome, using microarray technology and next generation sequencing of nucleic acids. Candidate genes are subsequently validated functionally in vitro and in vivo. Integration of such data allows identification of molecular pathways and networks that can be specifically targeted. In order to translate these findings into clinical settings, inhibitors of predicted targets are tested in preclinical models.